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Although epigenetic regulatory mechanisms have been confirmed as key intervention links, relevant research is still weak, and it is necessary to strengthen studies on the role of non-coding RNAs such as circRNA, lncRNA, and miRNA, as well as DNA/histone modifications in mediating the effects of natural products (Gamen et al., 2016

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serious systemic toxicity and rhabdomyolysis have been reported at mega-doses (~6 mg) [4]

Contraindications across the group commonly include pregnancy or breastfeeding and being under 18, with additional considerations such as active or recent cancer (CJC + Ipamorelin, IGF-1 LR3), active malignancy (Sermorelin), uncontrolled blood sugar disorders (CJC + Ipamorelin), uncontrolled metabolic or endocrine disorders (IGF-1 LR3, MOTS-C), severe liver or kidney disease (MOTS-C), autoimmune disorders requiring careful metabolic regulation (MOTS-C), and use of insulin or oral hypoglycaemic medications due to hypoglycaemia risk (MOTS-C)